creos xenogain - 3 methods of application to meet all your bone grafting needs

creos™ xenogain

Three methods of application to meet all your bone grafting needs.

Regenerating bone for 15 years

Three different methods of application

The portfolio offers a selection of xenogenic bone substitute for guided bone regeneration (GBR) and guided tissue regeneration (GTR).

creos xenogain is provided sterile and is available in a vial, in a syringe, or a bowl for fast and easy application.

creos xenogain - 3 methods of application to meet all your bone grafting needs

creos xenogain particles are made of deproteinized bovine bone mineral matrix with preserved micro- and macrostructures.1

The scaffold for successful regeneration

creos xenogain is characterized by a preserved natural bone matrix and interconnected pore system.1 The graft offers a suitable environment for new bone formation.1,2,3

Treat your patients with confidence

creos xenogain is biocompatible.3 Quality-controlled processing methods remove the bovine proteins and lipids.1

Why creos xenogain?


Chemical composition: Ca/P ratio

Interconnected macropores1,4


Osteoconductive properties4

Long-term volume stability5

Uneventful healing2,3,5,6,7


Homogenous particle size1

Hydrophilic for fast rehydration2,3


"I appreciated its handling properties and I see its high hydrophilicity as a biological advantage in sinus grafting and peri-implant defect regeneration.”


Scaffold for successful regeneration

Preserved natural features of bone through optimized manufacturing process.4

Chemical composition

With a calcium phosphate ratio that reflects the composition in human bone and a structure with low crystallinity.

The body accepts creos xenogain as a suitable framework for bone formation.1

creos xenogain SEM image

Solid foundation for implant placement

The graft integrates with the newly formed bone, building a basis for successful implant placement.2

creos xenogain - solid foundation for implant placement

In a multicenter clinical study involving 46 patients, bone increase after 8 months was 4.0 mm (+56.9 % gain) and 4.7 mm (51.0 % gain) at 1 and 3 mm from the top of the crest, respectively.6

GBR led to robust bone regeneration during the 8 months of healing, enabling successful placement of 91 implants in 43 patients, with an average insertion torque of 37.8 ± 5.1 Ncm.6


Questions about creos xenogain?

If you would like additional information, more details, or have specific questions about creos xenogain, click the link below.


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  1. Nobel Biocare, data on file.
  2. Park JB, et al. Maxillary sinus floor augmentation using deproteinized bovine bone-derived bone graft material (OCS-B). Clinical and histologic findings in humans. The Journal of the Korean Dental Association. 2007;45(8):491–99.
  3. Park HN, Han, SH, Kim KW, et al. A study on the safety and efficacy of bovine bone-derived bone graft material (OCS-B). J Korean Acad Periodontol. 2005 Jun;35(2):335–43.
  4. Rhee S-H, Park HN, Seol Y-J et al. Effect of heat-treatment temperature on the osteoconductivity of the apatite derived from bovine bone. 2006 Key Engineering Materials 309-311:41-44
  5. Shin S-Y, et al. Long-term results of new deproteinized bovine bone material in a maxillary sinus graft procedure. J Periodontal Implant Sci.2014;44;259-64.
    Read on Pubmed
  6. Aleksic Z, Milikovic I, Laziv Z, et al. A multicenter clinical investigation demonstrates bone regeneration in severe horizontal defects in the posterior mandible using creos™ xenoprotect: Interim results. J Clin Periodontol 2018;45(S19):306.
    Read poster
  7. Kim Y-T, Periodontal Repair on Intrabony Defects treated with Anorganic Bovine-derived Xenograft.J Korean Acad Periodontol. 2007;37(3):489–96.