creos mucogain

A natural collagen matrix for soft tissue regeneration

creos mucogain is a natural collagen matrix suitable for various soft-tissue indications such as soft-tissue volume augmentation and root coverage in submerged healing.*

creos mucogain

In submerged healing indications, creos mucogain substitutes the need for a second surgical site to harvest soft tissue. This avoids the post-operative pain, bleeding, swelling and infection associated with grafting procedures1-3, as well as limits on the quantity of harvestable soft tissue for grafting.


A choice of different sizes and thicknesses. Designed to replace autologous graft material in several indications.4

Excellent handling
Use straight from the box. Trim to precisely fit the surgical site.5

Mechanical strength
Memory effect: after hydration and cyclic handling simulations in-vitro, the graft retains its initial volume.4 High suture retention and stress resistance.4

Patented method
For producing an open interconnecting porous structure6 that is designed to promote soft-tissue regeneration through the migration of cells and blood vessels into the matrix.4,7

Clinically effective
For soft-tissue regeneration in submerged healing in combination with immediate implant placement and bone grafting procedure.5,8

Scientific evidence

creos mucogain: open interconnecting porous structure. courtesy of Matricel GmbH, Herzogenrath, Germany

Open interconnecting porous structure

  • Open interconnecting porous structure produced by a patented process6
  • Designed to promote soft-tissue regeneration through the migration of cells and blood vessels into the matrix4,7
Stress resistance for easy handling. Courtesy of Bastian Wessing.

Mechanical strength

  • High suture retention when dry and hydrated to enable fixation with sutures4
  • Suture pull-out strength is sufficient for tunneling technique5

Memory effect

When hydrated, the initial volume of the graft is maintained after repeated compression.4


Dr. Wessing

“Easy to use with nice handling. The soft tissue responds very well to the material with no foreign body reaction in my patients. A beneficial and promising material.”
Dr. Bastian Wessing, Germany

Dr. Fabbri

“creos mucogain can be used in many clinical situations achieving a satisfactory soft tissue stability with simplified approaches, avoiding harvest-sites morbidity.”
Dr. Giacomo Fabbri, Italy

Dr. Menendez

“It felt like an autogenous tissue graft and the mechanical stability is amazing.”
Dr. Miguel González Menéndez, Spain

* See Instructions For Use for full prescribing information, including indications, contraindications, warnings and precautions.


1 Aguirre-Zorzano LA, García-De La Fuente AM, Estefanía-Fresco R, et al. Complications of harvesting a connective tissue graft from the palate. A retrospective study and description of a new technique. J Clin Exp Dent 2017;9(12):e1439-e1445.

2 Griffin TJ, Cheung WS, Zavras AI, et al. Postoperative complications following gingival augmentation procedures. J Periodontol 2006;77(12):2070-2079.

3 Harris RJ, Miller R, Miller LH, et al. Complications with surgical procedures utilizing connective tissue grafts: a follow-up of 500 consecutively treated cases. Int J Periodontics Restorative Dent 2005;25(5):449-459.

4 Olde Damink L, Heschel I, Leemhuis H, et al. Soft tissue volume augmentation in the oral cavity with a collagen-based 3D matrix with orientated open pore structure. Current Directions in Biomedical Engineering 2018;4(1) [conference paper].

5 Wessing B, Vasilic N. Soft tissue augmentation with a new regenerative collagen 3-d matrix with oriented open pores as a potential alternative to autologous connective tissue grafts [329]. Clin Oral Implants Res 2014;25(s10):342. [poster presentation].

6 Heschel I, et al. 2002. Method for producing porous structures. US patent 6,447,701 B1.

Boekema B, Vlig M, Olde Damink L, et al. Effect of pore size and cross-linking of a novel collagen-elastin dermal substitute on wound healing. J Mater Sci Mater Med 2014;25(2):423-433.

8 Sanz‐Martín I, Encalada C, Sanz‐Sánchez I, et al. Soft tissue augmentation at immediate implants using a novel xenogeneic collagen matrix in conjunction with immediate provisional restorations: A prospective case series. Clin Implant Dent Relat Res 2018; doi: 10.1111/cid.12696. [Read the full article].