creos xenoprotect - a natural collagen membrane

Experience the resorbable collagen membrane with outstanding handling properties

Collagen membrane

creos xenoprotect is a resorbable dental membrane. A resorbable collagen membrane is used for guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures. 

It's composed of a network of interwoven, highly purified porcine collagen and elastin fibers, providing the membrane with high mechanical strength.

The fiber mesh holds the bone graft material securely in place, preventing undesired soft tissue from migrating into the bone augmentation site during bone healing.

Why creos xenoprotect?

Outstanding handling properties

A noticeable difference when applying the creos xenoprotect membrane is the ease of repositioning and unfolding as it doesn't become sticky when hydrated. It's rehydrated within seconds and adheres well to the defect shape. What's more, the membrane can be cut and pre-shaped according to the specific defect without having to consider any major size increase when moistened.1  

Easy to stretch and suture

creos xenoprotect is highly tear resistant due to its high mechanical strength, and its elastin fibers make the membrane stretchable.2 This makes it easy to stretch over the defect area and suture without fear of rupturing the membrane.

Prior to GBR, the mean defect size was 4.4 ± 2.6 mm wide and 13.1 ± 2.6 mm high. Eight months after treatment the bone gain was 4.0 mm (56.9 %) and 4.7 mm (51.0 %) in width when measured 1 mm and 3 mm from the top of the crest, respectively. (5)

Designed to perform

In clinical studies, creos xenoprotect demonstrates good results in the treatment of dehiscence defects3 and in horizontal ridge augmentation procedures.4,5 In both applications, creos xenoprotect facilitates bone gain and supports successful implant placement.3,4,6

In preclinical studies, creos xenoprotect has been shown to play an active role in regulating bone-healing dynamics in vivo.7 In addition, as a natural collagen membrane that is not subjected to chemical cross-linking, creos xenoprotect exhibits an enduring resistance to degradation in vivo.2

Low surface expansion when hydrated. (1)

Low rates of complications

In clinical studies in patients with dehisced implant sites and horizontal bone defects, use of creos xenoprotect is associated with favorable healing with no major complications.3,4,5 Observed rates of wound dehiscence and membrane exposure are low when creos xenoprotect is used in guided bone regeneration.3,4,5

Three sizes - limited waste

Whether larger bone augmentations or smaller periodontal defects, the optimal fit can be found without extensive trimming. This limits waste and minimizes costs for you and your patients. creos xenoprotect is available in three different sizes: 15 x 20 mm, 25 x 30 mm and 30 x 40 mm.

Cases

Dr. Fabrice Clipet, France – Augmentation after immediate implant placement

Situation: 7 mm buccal probing and mild root resorption at upper central incisor (tooth #21).  

Solution: Removal of hopeless tooth with immediate placement of NobelActive implant, bone grafting with a mix of autogenous bone and deproteinized bovine bone matrix (DBBM), covered by a creos xenoprotect collagen membrane.

View case (PDF, 179 kB)

Prof. Dr. Mariano Sanz, Spain – Extraction socket preservation

Situation: Periapical infection and an open fistulous track toward the root of upper central incisor (tooth #21). Presence of a perio-endo lesion and tooth is extracted. Loss of the buccal bone plate so a lateral bone augmentation procedure is indicated.

Solution: Deproteinized bovine bone mineral (DBBM) is used as scaffold and creos xenoprotect as a protective barrier. An implant is placed after six months of uneventful healing.

View case (PDF, 230 kB)

Dr. Philippe Russe, France – Horizontal ridge augmentation

Situation: Trauma on both upper central incisors in 1994. Teeth were re-implanted and extraction done in November 2012.

Solution: Horizontal ridge augmentation using processed allogenic bone graft and a creos xenoprotect collagen membrane. Placement of two NobelActive implants after six months of healing.

View case (PDF, 725 kB)

Dr. Oscar Gonzalez-Martin, Spain – Extraction socket preservation

Situation: Fractured first maxillary left premolar, tooth extraction indicated.  

Solution: GBR procedure and delayed implant placement.

View case (PDF, 442 kB)

Dr. Javier Alandez, Spain – Extraction socket preservation

Situation: Fractured first maxillary left premolar, tooth extraction indicated. 

Solution: The defect is filled by using bovine hydroxyapatite. A creos xenoprotect collagen membrane is applied to cover the defect. After three months, reopening of the treated area shows complete regeneration of the initial defect.

View case (PDF, 367 kB)

Dr. Hadi Antoun, France – GBR and simultaneous implant placement

Situation: Extraction of two lower right molars indicated, vertical bone defect at first molar. 

Solution: GBR procedure using creos xenoprotect collagen membrane and simultaneous implant placement with a Brånemark System MK IV implant. Restorative solution using a NobelProcera Titanium Abutment and a screw-retained crown.

View case (PDF, 936 kB)

Dr. Bastian Wessing, Germany – Horizontal and vertical ridge augmentation of a knife-edge ridge

Situation: Missing teeth 46, 47. Late implant placement, bone quality D1, poor bone quantity.

Solution: Horizontal and vertical augmentation by GBR using creos xenoprotect collagen membrane with “tenting screw technique”.

View case (PDF, 811 kB)

Scientific evidence

Horizontal Ridge Augmentation with a Novel Resorbable Collagen Membrane: A Retrospective Analysis of 36 Consecutive Patients

Wessing B, Emmerich M, Bozkurt A.

Int J Periodontics Restorative Dent. 2016 Mar-Apr;36(2):179-87.

Read abstract

Download full study

Randomized, prospective, multi-center study evaluating creos xenoprotect versus Bio-Gide in dehiscence defects: Bone augmentation results

Bastian Wessing, Eduardo Montero, Istvan Urban, Werner Zechner, Christian Schuh, Javier Alández, Óscar González-Martín, Giovanni Polizzi, Silvio Meloni, Martin Emmerich, Ignacio Sanz.

EAO 2016.

Download poster

What is Guided Bone Regeneration (GBR) Capable of Today?

Dr med. dent Bastian Wessing, Dr med. dent. Martin Emmerich, MSc. 

Jahrbuch Implantologie (SPECIAL PRINT Edition 2014 • Volume 20).

Download special print

New Materials in GBR” and “Safe Bone Regeneration Through a New Collagen Membrane

Dr med. dent. Bastian Wessing, Dr. med. dent. Martin Emmerich, MSc.

Implantologie Journal Special Print (SPECIAL PRINT Edition 5/11 and 5/12 • Volume 16).

Download special print

Tissue dynamics and regenerative outcome in two resorbable non-cross-linked collagen membranes for guided bone regeneration: A preclinical molecular and histological study in vivo.

Omar O, Dahlin A, Gasser A, Dahlin C. Clin Oral Implants Res 2018;29(1):7–19.

Read more

Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study

Bozkurt A, Apel C, Sellhaus B, van Neerven S, Wessing B, Hilgers R-D, Pallua N.

Clin Oral Implants Res. 2014 Dec; 25(12): 1403-11.*

* Since 2013 the Remaix™ membrane (Matricel GmbH, Germany) has been marketed as creos xenoprotect by Nobel Biocare.

Read abstract

Mechanical stability of collagen membranes: an in vitro study

Gasser A, Wessing B, Eummelen L, Büren A, Leemhuis H. 

AADR 2016.

Read poster abstract

Download poster

Resorbable Collagen Membranes Expansion In Vitro

Arrighi I, Wessing B, Rieben A, De Haller E.

J. Dent. Res 93 (Special Issue B):#631, 2014 (www.iadr.org).

Read poster

GBR with a mechanically stable resorbable membrane as a potential alternative to autogenous bone block grafts.

Wessing B, Bozkurt A, Sellhaus B, Emmerich M. 

Clin Oral Impl Res. October 2013:24(Supplement s9);153-154. DOI:10.1111/clr.12249.

Read poster abstract

Download poster

Study of a new collagen membrane with extended resorption time.

Wessing B, Emmerich M, Sellhaus B, Bozkurt A.

Clinical Oral Implants Research. October 2012:23(7):211.

Read poster abstract and poster

Testimonials

Prof. Christer Dahlin, Sweden

Prof. Christer Dahlin, Sweden

“I really like the handling of the material. The fact that it doesn’t lose its shape when you place it, is a great benefit. It gives you the possibility to take out the membrane and trim it. After a minute or so, when it is soaked, it attaches very nicely to the bone surface and no fixation seems to be necessary.”

Dr. Ramón Buenechea, Spain

Dr. Ramón Buenechea, Spain

“It is a thin, easy to handle and quickly moistened membrane that maintains its properties as a barrier. It allows suturing and/or tag fixation and is easily adapted to the bone defect.”

Dr. Angel Fernandez Bustillo, Spain

Dr. Angel Fernandez Bustillo, Spain

“For over a decade I have used collagen membranes to achieve excellent results.  Each type of membrane offered varying benefits. Nobel Biocare has managed to integrate most of them. I was surprised by its rapid and uniform hydration. It is easy to cut and it does not fold itself together. It is ideal for maxillary sinus lift and bone regeneration.”

Dr. Ali Tahmaseb, Netherlands

Dr. Ali Tahmaseb, Netherlands

“I like the membrane because it's very easy to handle compared to other membranes I’ve used. The most important thing for me is the extended resorption time – the membrane stays in place longer.”

Private practice, Antwerp, Belgium

Dr. Bastian Wessing, Germany

Dr. Bastian Wessing, Germany

“We have better results with creos xenoprotect than with the membranes we have used before. What I like is that the handling is very easy. The mechanical stability is very high and when it is rehydrated it adapts very well to the underlying bone.”

Dr. Bastian Wessing, Germany

Dr. Michael Danesh-Meyer, New Zealand

“My early experience with this membrane, both intra-operatively and post-operatively, has been positive. Post-operatively, I like the fact that I see very little inflammation. 10 days post suture removal, the tissues are looking pink. If you're using GBR in conjunction with your implant therapies, I would recommend this membrane."

Hear what he thinks

Dr. Hadi Antoun

Dr. Hadi Antoun, France

“I was pleasantly surprised to still find remnants of the creos xenoprotect membrane after six months. This long degradation time provides a greater chance of success.”

Literature

 

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References

1 Arrighi I, Wessing B, Rieben A, et al. Resorbable collagen membranes expansion in vitro. J Dent Res 2014;93(Spec Iss B):631 (www.iadr.org) [poster presentation].

Read the poster

2 Bozkurt A, Apel C, Sellhaus B, et al. Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study. Clin Oral Implants Res 2014;25(12):1403–1411.*

* Since 2013 the Remaix™ membrane (Matricel GmbH, Germany) has been marketed as creos xenoprotect by Nobel Biocare.

Read on Pubmed

3 Wessing B, Urban I, Montero E, et al. A multicenter randomized controlled clinical trial using a new resorbable non-cross-linked collagen membrane for guided bone regeneration at dehisced single implant sites: interim results of a bone augmentation procedure. Clin Oral Implants Res 2017;28(11):e218–e226.

Read on Pubmed

4 Wessing B, Emmerich M, Bozkurt A. Horizontal ridge augmentation with a novel resorbable collagen membrane: a retrospective analysis of 36 consecutive patients. Int J Periodontics Restorative Dent 2016;36(2):179–187.

Read on Pubmed

5 Aleksic Z, Milinkovic I, Lazic Z, et al. A multicenter clinical investigation demonstrates bone regeneration in severe horizontal defects in the posterior mandible using creos xenoprotect: interim results [PR546]. J Clin Periodontol 2018;45(S19):306 [poster presentation].

Read the abstract

6 Sanz-Sanchez I, Wessing B, Polizzi G, et al. Randomized clinical trial comparing two resorbable collagen membranes demonstrates good bone formation and soft tissue healing with GBR at single implant sites with dehiscence defects [O040]. J Clin Periodontol 2018;45(S19):19–20 [oral presentation].

Read the abstract

7 Omar O, Dahlin A, Gasser A, et al. Tissue dynamics and regenerative outcome in two resorbable non-cross-linked collagen membranes for guided bone regeneration:A preclinical molecular and histological study in vivo. Clin Oral Implants Res 2018;29(1):7–19.

Read on Pubmed