creos™ xenogain

Three methods of application to meet all your bone grafting needs.

Regenerating bone for 15 years

Why creos™ xenogain?

Similar to human bone

Chemical composition: Ca/P ratio 
Interconnected macropores1,4

Solid foundation for dental implant treatment

Osteoconductive properties4
Long-term volume stability5
Uneventful healing2,3,5,6,7 

Easy handling

Homogenous particle size1
Hydrophilic for fast rehydration2,3  

Three different methods of application

The portfolio offers a selection of xenogenic bone substitute for guided bone regeneration (GBR) and guided tissue regeneration (GTR).

creos™ xenogain is provided sterile and is available in a vial, in a syringe, or a bowl for fast and easy application.

    creos™ xenogain

    creos™ xenogain particles are made of deproteinized bovine bone mineral matrix with preserved micro- and macrostructures.1

    The scaffold for successful regeneration

    creos™ xenogain is characterized by a preserved natural bone matrix and interconnected pore system.1 The graft offers a suitable environment for new bone formation.1,2,3

    Treat your patients with confidence

    creos™ xenogain is biocompatible.3 

    Quality-controlled processing methods remove the bovine proteins and lipids.1

    creos xenogain product portfolio

    Dr. Werner Zechner

    Austria

    "I appreciated its handling properties and I see its high hydrophilicity as a biological advantage in sinus grafting and peri-implant defect regeneration.”

    creos™ xenogain collagen

    Purified cancellous bovine bone mineral granules and 10% porcine collagen in syringe and block form.

    The collagen helps to hold creos™ xenogain collagen in the desired place.

    Especially recommended for extraction socket management.

    creos xenogain collagen

    Scaffold for successful regeneration

    Preserved natural features of bone through optimized manufacturing process.4

    Chemical composition

    With a calcium phosphate ratio that reflects the composition in human bone and a structure with low crystallinity.

    The body accepts creos™ xenogain as a suitable framework for bone formation.1

    xenogain details

    Solid foundation for implant placement

    The graft integrates with the newly formed bone, building a basis for successful implant placement.2

    xenogain before and after

    In a multicenter clinical study involving 46 patients, bone increase after 8 months was 4.0 mm (+56.9 % gain) and 4.7 mm (51.0 % gain) at 1 and 3 mm from the top of the crest, respectively.6

    GBR led to robust bone regeneration during the 8 months of healing, enabling successful placement of 91 implants in 43 patients, with an average insertion torque of 37.8 ± 5.1 Ncm.6

    Questions about creos™ xenogain?

    If you would like additional information, more details, or have specific questions about creos™ xenogain, click the link below.

    Regeneratives courses

    Courses

    Find a course on hard and soft tissue management

    References

    1. Nobel Biocare, data on file.

    2. Park JB, et al. Maxillary sinus floor augmentation using deproteinized bovine bone-derived bone graft material (OCS-B). Clinical and histologic findings in humans. The Journal of the Korean Dental Association. 2007;45(8):491–99.

    3. Park HN, Han, SH, Kim KW, et al. A study on the safety and efficacy of bovine bone-derived bone graft material (OCS-B). J Korean Acad Periodontol. 2005 Jun;35(2):335–43.

    4. Rhee S-H, Park HN, Seol Y-J et al. Effect of heat-treatment temperature on the osteoconductivity of the apatite derived from bovine bone. 2006 Key Engineering Materials 309-311:41-44

    5. Shin S-Y, et al. Long-term results of new deproteinized bovine bone material in a maxillary sinus graft procedure. J Periodontal Implant Sci.2014;44;259-64. 
    Read on Pubmed

    6. Aleksic Z, Milikovic I, Laziv Z, et al. A multicenter clinical investigation demonstrates bone regeneration in severe horizontal defects in the posterior mandible using creos™ xenoprotect: Interim results. J Clin Periodontol 2018;45(S19):306. 
    Read poster

    7. Kim Y-T, et.al. Periodontal Repair on Intrabony Defects treated with Anorganic Bovine-derived Xenograft.J Korean Acad Periodontol. 2007;37(3):489–96.