creos xenoprotect - a membrane with outstanding handling that facilitates bone gain.

creos™ xenoprotect

A membrane with outstanding handling1,2 that facilitates bone gain.2-7

A resorbable collagen membrane for guided bone regeneration and guided tissue regeneration procedures.

Why creos xenoprotect?

Implant survival rate and implant success rate are excellent8 with a high percentage of defect fill.4

Active role in regulating bone-healing dynamics in vivo6

In a comparative in vivo study, creos xenoprotect demonstrated significantly higher new bone formation in the central portion of the defect. This increase in bone formation was associated with significantly increased expression of the growth factor Bmp2, which has a strong role in osteogenesis.6

Uneventful wound healing7

Low rates of wound dehiscence and membrane exposure have been reported in clinical studies.2,4,7

Designed to perform with low rates of complications2,4,7


Does not stick to instruments

Repositioning in-situ possible

Low surface expansion when hydrated

Both sides can face the defect


Excellent suture retention

Highly tear-resistant



Manufacturing process intended to preserve the natural structure of the collagen fiber network, to confer a high resistance to degradation

*As shown in an animal model (rat, subcutaneous)


“What I like is that the handling is very easy. The mechanical stability is very high and when it is rehydrated it adapts very well to the underlying bone.”

Facilitates new bone formation2-7

In a randomized controlled clinical trial, 24 patients were treated with creos xenoprotect and 25 with a reference membrane. In the creos xenoprotect group, the defect height reduced at 6-month re-entry by 81%. In the reference membrane group, the defect height reduced at 6-month re-entry by 62%.4

This schematic shows the defect height prior to treatment and 6 months after GBR.

creos xenoprotect SEM image courtesy of Schüpbach

A natural barrier with outstanding handling properties

Composed of a network of interwoven, highly purified porcine collagen and elastin fibers, providing the membrane with high mechanical strength.


“I use the creos xenoprotect membrane combined with creos xenogain particularly in cases of guided bone regeneration. The membrane, stabilized by pins, offers significant strength and stability."

creos xenoprotect Instructions For Use

Important information on, and instructions for, creos xenoprotect.

Questions about creos xenoprotect?

If you would like additional information, more details, or have specific questions about creos xenoprotect, click the link below.

creos xenoprotect webinar with Dr. Fabrizio Colombo

Webinar with Dr. Fabrizio Colombo

Choosing material and techniques for the treatment and prevention of bone resorption.


From our blog


Find a course on hard and soft tissue management


See Instructions For Use for full prescribing information, including indications, contraindications, warnings and precautions. 

  1. Arrighi I, Wessing B, Rieben A, et al. Resorbable collagen membranes expansion in vitro. J Dent Res 2014;93 (Spec Iss B):631.
    Read poster 
  2. Wessing B, Emmerich M, Bozkurt A. Horizontal ridge augmentation with a novel resorbable collagen membrane: a retrospective analysis of 36 consecutive patients. Int J Periodontics Restorative Dent 2016;36(2):179–187.
    Read on PubMed
  3. Bozkurt A, Apel C, Sellhaus B, et al. Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study. Clin Oral Impl Res; 25(S12):1403-1411.
    Read on Pubmed
  4. Wessing B, Urban I, Montero E, et al. A multicenter randomized controlled clinical trial using a new resorbable non-cross- linked collagen membrane for guided bone regeneration at dehisced single implant sites: interim results of a bone augmentation procedure. Clin Oral Impl Res;28(S11):e218–e226.
    Read on Pubmed
  5. Sanz-Sanchez I, Wessing B, Polizzi G, et al. Randomized clinical trial comparing two resorbable collagen membranes demonstrates good bone formation and soft tissue healing with GBR at single implant sites with dehiscence defects. J Clin Periodontol 2018;45(S19):19–20 [oral presentation].
    Read the abstract
  6. Omar O, Dahlin A, Gasser A, et al. Tissue dynamics and regenerative outcome in two resorbable non-cross-linked collagen membranes for guided bone regeneration:A preclinical molecular and histological study in vivo. Clin Oral Impl Res;29(S1):7–19.
    Read on Pubmed
  7. Aleksic Z, Milikovic I, Laziv Z, et al. A multicenter clinical investigation demonstrates bone regeneration in severe horizontal defects in the posterior mandible using creos™ xenoprotect: Interim results. J Clin Periodontol 2018;45(S19):306.
    Read the abstract
  8. Urban I, Wessing B, Alández N et al. A multicenter randomized controlled trial using a novel collagen membrane for guided bone regeneration at dehisced single implant sites: Outcome at prosthetic delivery and at 1‐year follow‐up. Clin Oral Impl Res;30(S6):487-497. 
    Read on PubMed
  9. Gasser A, Wessing B, Eummelen L, et al. Mechanical stability of collagen membranes: an in vitro study. J Dent Res 2016;95(Spec Iss A): 1683.
    Read the abstract