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NobelScience

The science behind the full-arch rehabilitation

Discover your go-to source for the latest breakthroughs in evidence-based innovation in full arch treatment concepts, including the original All-on-4® treatment concept.

Science First issue about the All-on-4 treatment concept

Science First Journal volume 6

Transforming lives with the All-on-4® treatment concept

Science in motion

Discover expert video insights focused on the latest innovations in edentulous patient care. Learn how precision implant placement, digital workflows, evidence-based treatment protocols, and high-quality prosthetic materials drive successful full-arch restorations.

Focus: All-on-4® treatment concept, FP1 and zygomatic solutions

Clinical case stories 

Explore our favorite clinical stories showcasing how experts approach complex edentulous cases, where patient-specific geometry—such as bone volume, sinus anatomy, and jaw structure—determines the choice of treatment. From zygomatic implants for severely resorbed maxillae to the All-on-4® concept for efficient full-arch restoration, these real-world examples highlight the power of advanced planning, surgical precision, and esthetic excellence. Each case reflects a commitment to predictable outcomes and patient satisfaction, supported by digital workflows, interdisciplinary collaboration, and premium implant systems. These stories are designed to inspire confidence and continuous learning in the field of edentulous rehabilitation.

Alexandra Marques and Ruben Davo

“The patient was told bone harvest and grafting was the only option.”

Severe maxillary atrophy and prior implant failure did not end this case. Discover how a hybrid All on 4® treatment with NobelZygoma enabled immediate function and a life changing outcome, as narrated by Dr. Ruben Davo and Alexandra Marques.

Explore the case >

Case courtesy of Drs. Moura and Lopes

10-year outcomes of NobelProcera® restoration in hybrid All-on-4® treatment concept

This case presents 10-year clinical outcomes following hybrid All-on-4® rehabilitation supported by a NobelProcera® titanium framework. It highlights how implant design, immediate function, and a high-quality screw-retained ceramic bridge contribute to long-term stability and predictable performance.

View the case report >

Ernest Orphanos

A facial analysis–based approach to predictable full-arch esthetics

Successful full arch implant treatment planning extends beyond oral anatomy to comprehensive facial analysis, supporting predictable functional and esthetic outcomes in edentulous patients using the All on 4® treatment concept and the Nobel Biocare N1 implant system.

See the clinical outcome >

Dr. Roberto Sleiter

From failing dentition to a confident smile, in just one day

This case highlights how anatomy‑driven planning, implant selection based on bone quality, and clear patient communication support predictable outcomes and long‑term compliance.

Review the clinical approach >

Editor's pick

Peer tips 

 Hear directly from experienced clinicians as they share their evidence-based approaches to full-arch rehabilitation in edentulous patients, including the use of zygomatic implants and the All-on-4® treatment concept. From straightforward cases to the most challenging anatomical scenarios, each insight is backed by published clinical studies, underscoring the importance of scientific rigor, surgical precision, and premium implant materials in achieving predictable, long-term outcomes.

Explore how modern protocols – supported by digital planning, high-performance components, and interdisciplinary collaboration – restore function, aesthetics, and confidence in patients living without natural teeth.

  • Long term outcomes in rehabilitation of the severely atrophic maxilla 

    Rehabilitation of the severely atrophic maxilla remains one of the most complex challenges in implant dentistry. In this interview, Dr. Rubén Davó shares long term clinical insights from up to 17 years of follow up on the quad zygoma protocol, explaining why an anatomy guided approach improves predictability, how complications are managed, and what the data reveals about patient outcomes and quality of life.

    Dr. Rubén Davó
    Read more in this interview
  • A surgeon’s perspective on leadership and impact

    In this interview, Dr. Alexandra Marques reflects on her journey as a female oral and maxillofacial surgeon in a traditionally male‑dominated specialty. She shares candid insights on representation, mentorship, and the role the industry can play in fostering inclusion, while also discussing the clinical impact of the All‑on‑4® treatment concept and her experience in FOR’s Emerging Leader Program.

    Alexandra Marques
    Explore this interview
  • Evidence-based choices in full-arch rehabilitation

    In this interview, Prof. Enrico Agliardi explains how long-term clinical evidence informs his decision-making in the treatment of edentulous patients. Drawing on up to 17 years of follow-up, he discusses when to choose the All-on-4® treatment concept, how residual bone guides treatment selection, and why implant design and strict protocol adherence are critical for predictable outcomes in complex cases.

    Prof. Enrico Agliardi
    Read the full interview
  • All-on-4® treatment concept in compromised bone anatomy

    In this interview, Prof. de Araújo Nobre discusses whether edentulous patients with compromised bone anatomy can be predictably treated with the All-on-4® treatment concept. Drawing on 10-year clinical data, he explains how dehiscence and fenestrations were managed, what complication rates were observed, and why proper maintenance and surgical experience are critical for long-term success in complex cases.

    Prof. de Araújo Nobre
    Explore the interview

Science Hub (ready to download)

Access print-ready summaries of key clinical studies focused on single-tooth rehabilitation – whether in the anterior or posterior region, maxilla or mandible. These resources highlight outcomes achieved with scientifically proven protocols and premium solutions. Explore white papers that bring together multiple studies to tell a complete story of clinical success, esthetic excellence, and long-term reliability.

White papers and newsletters

TiUltra osseointegration white paper

Successful clinical outcomes with TiUltra™ surface: Emerging data

A focused synthesis of current evidence, clinical approaches, and technological innovations in zygomatic implant therapy. Open access.

Clinical studies

Nobel Biocare N1™ implant system: One versatile and simplified solution for clinical success in all indications

3.5 year evidence: Zygomaztic solutions in edentulous maxilla

Procera® zirconia bridge in long-term

Excellent peri-implant tissues with Xeal™ and TiUltra™ surfaces for All-on-4® treatment concept

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