NobelScience

The science behind the single-tooth restoration

Replacing a single tooth is complex. Explore evidence and expert insights on biology‑driven planning, implant positioning, and restorative precision. 

The latest issue of the Science First journal is out

Esthetic edge: The science behind owning the zone

Esthetic edge: The science behind owning the zone

Science in motion

Hear directly from clinicians as they explain the "why" behind predictable single-tooth protocols – what to prioritize, what to avoid, and how to plan for long-term tissue stability. 

Clinical case stories

Take a read through our favorite clinical stories to see how experts approach complex cases – from missing lateral incisors to trauma rehabilitation. These real-world examples showcase advanced planning, surgical precision, and esthetic outcomes that inspire confidence and learning.

Single tooth Science
    Single tooth replacement in a thin biotype: A staged implant and digital prosthetic approach
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    Ann Wei

    Dr. Ann Wei presents a clinical case of single-tooth replacement in the esthetic zone of a patient with a thin gingival biotype, where maintaining soft tissue stability is particularly challenging

    Review the clinical approach

    “There is no anterior case in which I don’t consider FIIPP first.”
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    Dr. Edith Groenendijk

    Dr. Edith Groenendijk presents FIIPP protocol enabling flapless immediate implant placement with N1 system, preserving soft tissue, optimizing positioning, and delivering predictable esthetic outcomes.

    Review the clinical approach

    See how NobelActive 3.0 solves narrow space challenges
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    Hagan

    Dr. Mark Hagan shares a detailed clinical case on restoring congenitally missing lateral incisors with implant therapy designed for long-term stability and esthetics.

    View the case report

    A metal-free solution for restoring natural esthetics
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    Tartsch

    With Dr. Jens Tartsch, explore metal‑free restorative dentistry that combines natural esthetics, biocompatibility, and strength, demonstrated through a documented clinical case with precision and predictable, patient‑centered outcomes.

    Explore the case

    A stepwise approach to esthetic zone reconstruction: clinical case insights
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    Todescan

    Discover how Prof. Francisco Todescan and his team approach esthetic zone reconstruction, where thoughtful implant planning and refined soft‑tissue management deliver predictable, natural‑looking anterior outcomes.

    See the clinical outcome

    Rehabilitation of anterior maxilla with limited spaces after traumatic injury
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    Lundgren

    Join Prof. Stefan Lundgren as he shares advanced strategies for rehabilitating the anterior maxilla after trauma—combining smart implant planning, esthetic control, and predictable results in limited spaces.

    Review the clinical approach

    Editors pick

    Peer tips

    Learn directly from experienced clinicians as they share their evidence-based approaches to single-tooth rehabilitation, from straightforward cases to the most challenging scenarios. Each insight is backed by their research and published studies, highlighting the importance of scientific rigor, precision, and premium materials in achieving predictable outcomes.

    membrane exposure

    Membrane exposure: clinical view. A multicenter study on creos™ biomaterials for GBR in large horizontal defects revealed strong bone gain and high patient satisfaction. Interviews with Drs. Lorenz and Magic emphasized the importance of managing dehiscence and membrane exposure with minimal intervention, highlighting the value of PROMs and the handling properties of creos™ xenoprotect.

    Explore this multi-center clinical study 

      Procera™ restorations in single tooth indication: low complication rate

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      Prosthetic survival rate

      A multicenter study of 463 CAD/CAM NobelProcera® individualized abutments shows a 98.1% prosthetic survival rate and just 1.5% technical complications over 6.4 years. With high patient and clinician satisfaction, these fully screw-retained solutions demonstrate long-term reliability and esthetic success.

      Explore this clinical study

      What 15 years taught us: Evidence based planning

      A 15-year retrospective study conducted by Drs. Jan Kowar, Henrik Lund, and Victoria Franke Stenport evaluated 129 TiUnite surface implants used in single-tooth restorations. The results showed a high survival rate and minimal complications, with stable bone levels and low incidence of peri-implantitis. The study underscores the importance of careful planning, precise placement, and patient compliance for long-term implant success.

      Explore the 15-year study on single-tooth implant success

      “We can’t plan a smile without understanding how it fits into the patient’s facial dynamics."

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      Francesco Mintrone

      Implant planning by Dr. Francesco Mintrone integrates digital planning and socket shield technique to enhance esthetic outcomes, precision, and long term tissue stability.

      Read the full interview

      Immediate implants in extraction socket

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      Immediate implants

      Dr. Iñaki Gamborena presents clinical insights on immediate implant placement in fresh extraction sockets, emphasizing the importance of soft tissue management and prosthetic planning. His approach highlights how careful timing and anatomical considerations can lead to predictable esthetic outcomes and long-term success. The article showcases his technique and rationale for achieving optimal results in challenging cases.

      Learn Dr. Gamborena’s approach to immediate implant placement.

      “Progress in implants with no change in protocol appeals a lot to my trainees”

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      Implant systems

      Dr. Bobby Birdi highlights how Nobel Biocare’s implant systems particularly NobelActive enable clinical progress without requiring changes to established protocols. This consistency appeals to trainees and clinicians alike, offering predictable outcomes and streamlined workflows. The article emphasizes how maintaining protocol stability can support both learning and long-term success in implantology.

      Explore Dr. Birdi's views on these surfaces

      Science Hub (ready to download)

      Access print-ready summaries of key clinical studies focused on single-tooth rehabilitation – whether in the anterior or posterior region, maxilla or mandible. These resources highlight outcomes achieved with scientifically proven protocols and premium solutions. Explore white papers that bring together multiple studies to tell a complete story of clinical success, esthetic excellence, and long-term reliability.

      White papers and newsletters

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      GMT88000

       

      Nobel Biocare N1™ implant system: Precision engineering for clinical predictability

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      GMT82758

       

      NobelPearl™: metal-free two-piece implant solution

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      xenoform

       

      creos™ xenoform: an all-cancellous bone graft

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      GMT89337

       

      Successful clinical outcomes with TiUltra™ surface: Emerging data

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      creos xenoprotect

       

      creos™ xenoprotect: strong native collagen membrane

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      Clinical studies

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      GMT86269

       

      Robust papilla regeneration and marginal bone gain with Xeal™ and TiUltra™ surfaces: 2-year results

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      GMT85946

       

      15 years of clinical success: single-tooth restoration with anodized implants

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      GMT81062

       

      Nobel Biocare N1™ concept: biologically friendly innovation reduces cell death

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      GMT82664

       

      Five years of esthetic excellence with NobelReplace® CC and NobelProcera® in the anterior maxilla

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      GMT89726

       

      Excellent long-term outcomes with NobelActive® and immediate protocols in esthetic zone

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      NobelActive

       

      Significantly increased soft tissue thickness around NobelActive® TiUltra™ and On1™ Base Xeal™ after 1 year

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      GMT83350

       

      Significantly increased soft tissue thickness around NobelActive® TiUltra™ and On1™ Base Xeal™ after 1 year

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      GMT81439

       

      Nobel Biocare N1™ concept: one versatile and simplified solution for clinical success in all indications

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      GMT77902

       

      NobelParallel™ CC implants support success, even in challenging situations

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      GMT84905

       

      Excellent prosthetic survival and low complication rate with 463 CAD/CAM NobelProcera® abutments

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      GMT82621

       

      Successful horizontal ridge regeneration in the posterior mandible using creos™ biomaterials

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