A resorbable collagen membrane for guided bone regeneration and guided tissue regeneration procedures.

Outstanding handling1,2

Does not stick to instruments 
Repositioning in-situ possible 
Low surface expansion when hydrated 
Both sides can face the defect 

High mechanical strength2,3,9

Excellent suture retention 
Highly tear-resistant 

Enduring resistance to degradation in vivo*3

Manufacturing process intended to preserve the natural structure of the collagen fiber network, to confer a high resistance to degradation

*As shown in an animal model (rat, subcutaneous)

Why creos™ xenoprotect?

Implant survival rate and implant success rate are excellent8 with a high percentage of defect fill.4

    Active role in regulating bone-healing dynamics in vivo⁶

    In a comparative in vivo study, creos xenoprotect demonstrated significantly higher new bone formation in the central portion of the defect. This increase in bone formation was associated with significantly increased expression of the growth factor Bmp2, which has a strong role in osteogenesis.6

    Uneventful wound healing⁷

    Low rates of wound dehiscence and membrane exposure have been reported in clinical studies.2,4,7

    Designed to perform with low rates of complications² ⁴ ⁷

    creos™ xenoprotect

    Facilitates new bone formation2-7

    In a randomized controlled clinical trial, 24 patients were treated with creos xenoprotect and 25 with a reference membrane. In the creos xenoprotect group, the defect height reduced at 6-month re-entry by 81%. In the reference membrane group, the defect height reduced at 6-month re-entry by 62%.4

    This schematic shows the defect height prior to treatment and 6 months after GBR.

    xenoprotect bone formation
    xenoprotect-SEM

    A natural barrier with outstanding handling properties

    Composed of a network of interwoven, highly purified porcine collagen and elastin fibers, providing the membrane with high mechanical strength.

    On-demand webinar with Dr. Fabrizio Colombo

    Choosing material and techniques for the treatment and prevention of bone resorption

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    Fabrizio Colombo

    Dr. Joe Mehranfar

    Phoenix, AZ

    "One of my favorite products is creos™ xenoprotect – this membrane is tough and resorbs to enable bone regeneration. It doesn't tear, allowing me to suture through it. Additionally, it is pliable so I can easily move it around once it’s wet. I love it!"

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    creos™ xenoprotect 
    Instructions For Use

    Important information on, and instructions for, creos xenoprotect.

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    Questions about creos™ xenoprotect?

    If you would like additional information, more details, or have specific questions about creos xenoprotect, click the link below.

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    References

    The allograft particulate, pericardium membrane and the dbm putty are currently available for order in the US and Canada only.

     

    1. Arrighi I, Wessing B, Rieben A, et al. Resorbable collagen membranes expansion in vitro. J Dent Res 2014;93 (Spec Iss B):631. 
    Read poster

    2. Wessing B, Emmerich M, Bozkurt A. Horizontal ridge augmentation with a novel resorbable collagen membrane: a retrospective analysis of 36 consecutive patients. Int J Periodontics Restorative Dent 2016;36(2):179–187.
    Read on PubMed

    3. Bozkurt A, Apel C, Sellhaus B, et al. Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study. Clin Oral Impl Res; 25(S12):1403-1411. 
    Read on Pubmed

    4. Wessing B, Urban I, Montero E, et al. A multicenter randomized controlled clinical trial using a new resorbable non-cross- linked collagen membrane for guided bone regeneration at dehisced single implant sites: interim results of a bone augmentation procedure. Clin Oral Impl Res;28(S11):e218–e226.
    Read on Pubmed

    5. Sanz-Sanchez I, Wessing B, Polizzi G, et al. Randomized clinical trial comparing two resorbable collagen membranes demonstrates good bone formation and soft tissue healing with GBR at single implant sites with dehiscence defects. J Clin Periodontol 2018;45(S19):19–20 [oral presentation].
    Read the abstract

    6. Omar O, Dahlin A, Gasser A, et al. Tissue dynamics and regenerative outcome in two resorbable non-cross-linked collagen membranes for guided bone regeneration:A preclinical molecular and histological study in vivo. Clin Oral Impl Res;29(S1):7–19. 
    Read on Pubmed

    7. Aleksic Z, Milikovic I, Laziv Z, et al. A multicenter clinical investigation demonstrates bone regeneration in severe horizontal defects in the posterior mandible using creos™ xenoprotect: Interim results. J Clin Periodontol 2018;45(S19):306. 
    Read the abstract

    8. Urban I, Wessing B, Alández N et al. A multicenter randomized controlled trial using a novel collagen membrane for guided bone regeneration at dehisced single implant sites: Outcome at prosthetic delivery and at 1‐year follow‐up. Clin Oral Impl Res;30(S6):487-497. 
    Read on PubMed

    9. Gasser A, Wessing B, Eummelen L, et al. Mechanical stability of collagen membranes: an in vitro study. J Dent Res 2016;95(Spec Iss A): 1683. 
    Read the abstract