TiUnite implant surface – proven to perform

Enhanced osseointegration and stable bone levels


What is TiUnite?

TiUnite dental implant surface

TiUnite is a high-performance implant surface that enhances osseointegration1 – even under the most challenging conditions.2-8 It is characterized by a moderately rough, thickened titanium oxide layer with high crystallinity and osteoconductive properties leading to faster bone formation.

The TiUnite surface has been proven to help maintain implant stability achieved at placement during the critical healing phase9 and anchorage in the surrounding bone, compared with machined implants.10,11 TiUnite surface implants can therefore play an important role in helping clinicians meet patient demand for immediate teeth.

5 reasons to choose implants with the TiUnite surface

1. Unparalleled scientific evidence

TiUnite is one of the most clinically researched implant surfaces on the market. Since its launch in 2000, it has been clinically documented in more than 465 publications on 382 clinical studies evaluating more than 89,500 implants, over 22,600 patients, and 11.2 years of longest mean follow-up.12

In the largest ever meta-analysis of a single implant brand,13 the TiUnite surface has set the scientific standard again, with outcomes from 4,694 clinically evaluated patients treated with 12,804 TiUnite implants reported in 106 prospective studies being analyzed.


2. Predictable osseointegration with minimal failure rates

The TiUnite implant surface was first introduced on the Brånemark System in 2000. This shift from machined to TiUnite surface resulted in a clear decrease in early failures, especially in areas with poor bone density.14,15

Incidence of dental implant early failures upon introduction of moderately rough surface

Lower incidence of early failures upon the introduction of moderately rough surface, primarily TiUnite surface implants, was significant in both jaws. Figure courtesy of Prof. Torsten Jemt, Sweden.

3. Stable marginal bone levels

After the initial bone remodeling phase, the TiUnite implant surface has shown stable marginal bone levels over the medium and long-term.13,16

Stable marginal bone levels with the TiUnite implant surface

4. Short- and long-term success

TiUnite maintains implant stability immediately after placement with enhanced osseointegration and anchorage in surrounding bone.1,9,17 In the long term, it maintains marginal bone and soft tissue levels, maximizing functional endurance and esthetics.13,16,18-23

Short and long term success of TiUnite implant surface

5. Low rates of peri-implantitis

The TiUnite implant surface demonstrated low prevalence of peri-implantitis24 at a rate comparable with other moderately rough implant surfaces.13,25

*Of 106 studies, 47 reported biological complications. Of these 47 papers, 19 reported cases of peri-implantitis in 5.2% of patients (64/1229). The authors concluded that, if peri-implantitis did not occur in studies where it was not explicitly reported, its prevalence would be 1.36%.

Clinical case

NobelActive supporting hard and soft tissue for 10 years

Immediate implant placement in a fresh extraction socket of a NobelActive RP implant 4.3 mm x 13 mm. Socket augmentation was performed, using xenograft and autogenous soft-tissue grafting harvested from the tuberosity area, to close the socket and increase the amount of soft tissue at the recipient site. A cement-retained lithium disilicate crown was cemented onto an anatomically shaped zirconia abutment.


Prof. Dr. Matthias Karl, Germany

"For me, TiUnite is a highly reliable implant surface even in very challenging situations. It’s a great surface that keeps the implant in place. The longevity is definitely there – and it's proven."


Prof. Tomas Albrektsson, Sweden

"The meta-analysis is another validation of TiUnite’s efficacy, but there is confirmation of its high performance also in other types of clinical studies. I observed TiUnite being launched in the year 2000. I believed in it then and now I know that my beliefs were correct. It is a superb implant surface."

Prof. Bertil Friberg from the Brånemark Clinic in Sweden explains why he likes TiUnite.

Prof. Bertil Friberg, Brånemark Clinic, Sweden

"The TiUnite surface has improved our results, especially in grafted bone and in bone of low density. It has, without question, significantly reduced our early failure rate as well."

Dr. Thomas Müller-Hotop from Germany explains why he uses TiUnite for all indications.

Dr. Thomas Müller-Hotop, Germany

"Ever since the TiUnite surface became available, we have used it for all indications in our dental office. We see major benefits in advanced indications such as immediate implant placement, immediate loading and implant placement in soft bone conditions."


Ivanoff CJ, Widmark G, Johansson C, et al. Histologic evaluation of bone response to oxidized and turned titanium micro-implants in human jawbone. Int J Oral Maxillofac Implants 2003;18:341-348.

Read on PubMed

Rocci A, Rocci M, Rocci C, et al. Immediate loading of Brånemark System TiUnite and machined-surface implants in the posterior mandible: a randomized open-ended clinical trial. Int J Oral Maxillofac Implants. 2013;28(3):891-895.

Read on PubMed

Kolinski ML, Cherry JE, McAllister BS, et al. Evaluation of a variable-thread tapered implant in extraction sites with immediate temporization: A 3-year multi-center clinical study. J Periodontol 2014;85:386-394.

Read on PubMed

Marzola R, Scotti R, Fazi G, et al. Immediate loading of two implants supporting a ball attachment-retained mandibular overdenture a prospective clinical study. Clin Implant Dent Relat Res 2007;9:136-143.

Read on PubMed

Arnhart C, Kielbassa AM, Martinez-de Fuentes R, et al. Comparison of variable-thread tapered implant designs to a standard tapered implant design after immediate loading. A 3-year multicentre randomised controlled trial. Eur J Oral Implantol 2012;5:123-136.

Read on PubMed

Glauser R. Implants with an oxidized surface placed predominately in soft bone quality and subjected to immediate occlusal loading: results from a 7-year clinical follow-up. Clin Implant Dent Relat Res 2013;15: 322-331.

Read on PubMed

Liddelow G, Henry P. The immediately loaded single implant-retained mandibular overdenture: a 36-month prospective study. Int J Prosthodont 2010;23:13-21.

Read on PubMed

Mura P. Immediate loading of tapered implants placed in postextraction sockets: retrospective analysis of the 5-year clinical outcome. Clin Implant Dent Relat Res 2012;14:565-574.

Read on PubMed

Glauser R, Portmann M, Ruhstaller P, et al. Stability measurements of immediately loaded machined and oxidized implants in the posterior maxilla. A comparative clinical study using resonance frequency analysis. Appl Osseointegration Res 2001;2:27-29.

10 Albrektsson T, Johansson C, Lundgren A-K, et al. Experimental studies on oxidized implants. A histomorphometrical and biomechanical analysis. Appl Osseointegrat Research 2000;1(1):21–24.

11 Omar OM, Lenneras ME, Suska F, et al. The correlation between gene expression of proinflammatory markers and bone formation during osseointegration with titanium implants. Biomaterials 2011;32(2):374–386.

12 TiUnite literature search. Nobel Biocare Services AG. July, 2017.

13 Karl M, Albrektsson T. Clinical performance of dental implants with a moderately rough (TiUnite) surface: a meta-analysis of prospective clinical studies. Int J Oral Maxillofac Implants 2017;32(4):717–734.

Read on PubMed

14 Balshi SF, Wolfinger GJ, Balshi TJ. Analysis of 164 titanium oxide surface implants in completely edentulous arches for fixed prosthesis anchorage using the pterygomaxillary region. Int J Oral Maxillofac Implants. 2005; 20:946-952

Read on PubMed

15 Jemt T, Olsson M, Franke Stenport V. Incidence of first implant failure: a retro-prospective study of 27 years of implant operations at one specialist clinic. Clin Implant Dent Relat Res 2015;17(Suppl 2):e501-e510.

Read on Pubmed

16 Östman PO, Hellman M, Sennerby L. Ten years later. Results from a prospective single-centre clinical study on 121 oxidized (TiUnite) Brånemark implants in 46 patients. Clin Implant Dent Relat Res 2012;14(6):852-860.

Read on PubMed

17 Zechner W, Tangl S, Furst G, et al. Osseous healing characteristics of three different implant types. Clin Oral Implants Res 2003; 14:150-157.

Read on PubMed

18 Degidi M, Nardi D, Piattelli A. 10-year follow-up of immediately loaded implants with TiUnite porous anodized surface. Clin Implant Dent Relat Res 2012;14(6):828-838.

Read on PubMed

19 Glauser R. Eleven-year results of implants with an oxidized surface placed predominantly in soft bone and subjected to immediate occlusal loading. Clin Oral Impl Res 2012; 23 (Suppl 7);140-141.11

Read on PubMed

20 Glauser R. Implants with an oxidized surface placed predominately in soft bone quality and subjected to immediate occlusal loading: results from an 11-year clinical follow-up. Clin Implant Dent Relat Res 2016;18(3):429-438.

Read on PubMed

21 Pozzi A, Mura P. Clinical and radiologic experience with moderately rough oxidized titanium implants: up to 10 years of retrospective follow-up. Int J Oral Maxillofac Implants 2014;29(1):152–161.

Read on PubMed

22 Imburgia M, Del Fabbro M. Long-term retrospective clinical and radiographic follow-up of 205 Branemark System Mk III TiUnite implants submitted to either immediate or delayed loading. Implant Dent 2015;24(5):533–540.

Read on PubMed

23 Froum SJ, Khouly I. Survival rates and bone and soft tissue level changes around one-piece dental implants placed with a flapless or flap protocol: 8.5-year results. Int J Periodontics Restorative Dent 2017;37(3):327–337.

Read on PubMed

24 Gelb D, McAllister B, Nummikoski P, Del Fabbro M. Clinical and radiographic evaluation of Branemark implants with an anodized surface following seven-to-eight years of functional loading. Int J Dent 2013:583567.

25 Albrektsson T, Buser D, Sennerby L. Crestal bone loss and oral implants. Clin Implant Dent Relat Res 2012;14(6):783-791.