A comprehensive range of xenogenic bone substitutes
The creos xenogain portfolio comprises an extensive range of non-sintered xenogenic bone substitutes for guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures.
The comprehensive range includes:
For quick and easy application of the graft, creos xenogain bone substitutes are delivered sterile and come either in a vial, in a syringe or in a bowl ready for mixing. Two granule sizes and up to four volume options offer a wide variety of alternatives.
creos xenogain is biocompatible.3,4,5,6 Unique processing methods remove the bovine proteins and lipids.1,2 With a calcium phosphate ratio that reflects the composition in human bone and a low crystalline structure, creos xenogain is accepted by the body as a suitable framework for bone formation.2,7,8
creos xenogain is characterized by a preserved natural bone matrix with micro- and interconnected macropore structures.1,2 It offers a suitable environment for new bone formation.2,3,4 creos xenogain promotes rapid hydration (capable to absorb 1.75x its weight of water mass in a few seconds).1
creos xenogain acts as a slowly resorbing scaffold and maintains space for bone regeneration.4 The graft integrates with the newly formed bone, building a basis for successful implant placement.
A composite of creos xenogain and 10% porcine collagen type 1 for easy graft application e.g. in extraction sockets, that is available as a block or a syringe.
Once the bone substitute is applied, the resorbable creos xenoprotect membrane can be used to hold it in place and act as a barrier to soft tissue ingrowth.
Situation: Hopeless tooth 11 after traumatic accident with discoloring, persistent pain and mobility grad II.
Solution: Immediate implant placement with gap augmentation using creos xenogain (small granules).
View case (PDF, 476 kB)
Situation: Missing central incisor due to trauma in childhood. Patient is under orthodontic treatment.
Solution: Implant placement (NobelActive 3.5 x 13 mm) with simultaneous bone augmentation using creos xenoprotect and creos xenogain (small granules 0.2 - 1.0 mm).
View case (PDF, 1 MB)
Situation: Chronic periodontitis. Tooth # 25 with porcelain fused to metal crown and metal post and core. Vertical root fracture occurred two months earlier. 10 mm “U” shaped buccal dehiscence.
Solution: Immediate implant placement (NobelParallel CC RP 4.3 x 13 mm) in combination with a GBR procedure (using creos xenogain and creos xenoprotect).
View case (PDF, 1 MB)
Situation: Missing tooth #12 with post extraction bony defect in coronal part of the ridge.
Solution: Delayed implant placement (NobelActive 3.0 x 13 mm) in combination with a GBR procedure (using creos xenogain and creos xenoprotect).
Situation: Missing teeth #15 and 16, with inadequate bone height for the implant placement due to maxillary sinus pneumatization.
Solution: Maxillary sinus floor elevation (using creos xenogain and creos xenoprotect) in combination with immediate implant placement (NobelParallel CC Ø 5.0 x 10 mm at 15 and NobelParallel CC Ø 5.0 x 10 mm at 16).
“What impressed me about this product was the variety of sizes and dosage forms, each offering very good handling properties.”
"After using the non-sintered creos xenogain bone substitute, I appreciated its handling properties and I see its high hydrophilicity as a biological advantage in peri-implant defect regeneration and sinus grafting."
“creos xenogain is a user-friendly bone grafting material: hydration, manipulation and positioning is simplified by its wettability coupled with a smart syringe packaging that really makes things easy.”
“What most impressed me about this product was the handling property and the fast integration.”
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1 Data on file NIBEC
2 Data on file Nobel Biocare Material properties of CXG / biomaterials
3 Park H-N, et al. A study on the safety and efficacy of bovine bone-derived bone graft material(OCS-B). J Korean Acad Periodontol. 2005 Jun;35(2):335–43
4 Park J-B, et al. Maxillary sinus floor augmentation using deproteinized bovine bone-derived bone graft material(OCS-B). Clinical and histologic findings in human. The Journal of the Korean Dental Association. 2007;45(8):491–99
5 Shin S-Y, et al. Long-term results of new deproteinized bovine bone material in a maxillary sinus graft procedure. J Periodontal Implant Sci. 2014;44:259–64
6 Data on file NIBEC Biocompatibility tests: OCS-B and OCS-B Collagen
7 Kyriazis V, Tzaphlidou M. Skeletal Calcium/Phosphorus Ratio Measuring Techniques and Results. I. Microscopy and Microtomography. The Scientific World Journal. 2004;4:1027–34
8 Data on file NIBEC Atomic emission spectrometry analysis
9 Data on file NIBEC Porosity Analysis (BET measurement)
