creos xenoprotect – experience the difference

The collagen membrane with outstanding handling properties and an extended barrier function.

creos xenoprotect – experience the difference

creos xenoprotect is a biodegradable collagen membrane for guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures. It is composed of a network of interwoven, highly purified porcine collagen and elastin fibers, providing the membrane with very high mechanical strength. The dense mesh holds the bone graft material securely in place, preventing the migration of undesired cells for undisturbed healing.

  • Reliable and long-lasting barrier function
    Due to the unique manufacturing process of creos xenoprotect, the membrane is highly resistant to degradation, leading to stable and prolonged protection of the graft material.1 This is achieved without any chemical cross-linking, ensuring optimal conditions for tissue integration.
  • Outstanding handling – saves you valuable time
    A noticeable difference when applying the creos xenoprotect membrane for the first time is the ease of repositioning and unfolding, as it does not become sticky when hydrated.
     
    The hydrophilic nature of the membrane means it is rehydrated within seconds2 and adheres well to the defect shape, often eliminating the need for additional fixation.

    Furthermore, the membrane can be cut and pre-shaped according to the specific defect when dry, without having to consider any major size increase when moistened.3
  • Easy to stretch and suture
    creos xenoprotect is highly tear resistant due to its high mechanical strength, and its elastin fibers make the membrane stretchable.1 This makes it easy to stretch over the defect area and suture without any fear of breaking the membrane.
  • Fast and predictable tissue healing
    Due to the avoidance of any chemical cross-linking during processing, the tissue integration and vascularization properties of the membrane are not compromised.2  
    Histologies clearly show the rapid formation of new blood vessels, which lead to faster and more predictable tissue healing.
  • 3 sizes - limited waste
    Whether larger bone augmentations or smaller periodontal defects, the optimal fit can be found without extensive trimming, limiting waste and minimizing costs for you and your patients. creos xenoprotect is available in three different sizes: 15x20mm, 25x30mm, and 30x40mm.
  • References

    1 Bozkurt et al. Clin Oral Impl Res. Epub 2013 Oct 23

    Bozkurt A, Apel C, Sellhaus B, van Neerven S, Wessing B, Hilgers R-D, Pallua N. Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study. Clin. Oral Impl. Res. 00, 2013, 1-9 doi: 10.1111/clr.12284 [Epub ahead of print]*

    *The non-cross-linked membrane "Remaix" is distributed by Nobel Biocare under the trade name "creos xeno.protect".

    2 Data on file, Matricel GmbH
    3 Data on file, Nobel Biocare
    Statistically significant lower size increase compared to standard cross-linked collagen membranes on the market.
Clipet case 115x115

Dr. Fabrice Clipet, France – Augmentation after immediate implant placement

Indication: 7mm buccal probing and mild root resorption at upper central incisor (tooth #21).  

Solution: Removal of hopeless tooth with immediate placement of NobelActive implant, bone grafting with a mix of autogenous bone and particulate xenograft, covered by a creos xenoprotect collagen membrane.

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Sanz case 115x115

Prof. Dr. Mariano Sanz, Spain – Extraction socket preservation

Indication: Periapical infection and an open fistulous track toward the root of upper central incisor (tooth #21). It presents a perio-endo lesion and tooth extraction is indicated. Loss of the buccal bone plate, lateral bone augmentation procedure is needed.  

Solution: Deproteinized bovine bone mineral (DBBM) is used as scaffold and creos xeno.protect collagen membrane as a protective barrier. Dental implant placed after 6 month of uneventful healing. 

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Russe case image

Dr. Philippe Russe, France – Horizontal ridge augmentation

Indication: Trauma on both upper central incisors in 1994. Teeth were re-implanted and extraction done in November 2012.

Solution: Horizontal ridge augmentation using processed allogenic bone graft and a creos™ xenoprotect porcine collagen membrane. Placement of two NobelActive implants after 6 months of healing. 

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Gonzales case image

Dr. Oscar Gonzalez-Martin, DMD, MSc, Spain – Extraction socket preservation

Indication: Fractured first maxillary left premolar, tooth extraction needed.  

Solution: GBR procedure and delayed implant placement.

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Case image

Dr. Javier Alandez, DMD, PhD, Spain – Extraction socket preservation

Indication: Fractured first maxillary left premolar, tooth extraction needed. 

Solution: The defect is filled using bovine hydroxyapatite. A creos xenoprotect porcine collagen membrane is used to cover the defect. After 3 months, re-opening of the treated area shows complete regeneration of the previous defect.

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Case_Tabanella 1

Dr. Giorgio Tabanella (DDS, MS), Italy – GBR and simultaneous implant placement

Indication: Missing mandibular first molar, crestal bone resorption.

Solution: GBR procedure using creos xenoprotect collagen membrane for augmentation of implant dehiscence after placement of a NobelReplace Conical Connection implant.

Case_Tabanella 2

Dr. Giorgio Tabanella (DDS, MS), Italy – Maxillary sinus elevation

Indication: Extraction of hopeless upper first molar, pneumatized maxillary sinus with insufficient bone volume for implant placement. 

Solution: Maxillary sinus elevation using creos xenoprotect to cover lateral window.

Case_Tabanella 3

Dr. Giorgio Tabanella (DDS, MS), Italy – Horizontal augmentation

Indication: Both upper lateral incisors missing, narrow ridge and insufficient bone volume for implant placement. 

Solution: GBR procedure using creos xenoprotect collagen membrane for horizontal ridge augmentation.

  • Bozkurt A et al.

    Bozkurt A, Apel C, Sellhaus B, van Neerven S, Wessing B, Hilgers R-D, Pallua N. Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study. Clin. Oral Impl. Res. 00, 2013, 1–9 doi: 10.1111/clr.12284 [Epub ahead of print]


    Read the study

  • Wessing et al. Clin Oral Impl Res. 2013 (Supplement s9)

    Wessing B, Bozkurt A, Sellhaus B, Emmerich M. GBR with a mechanically stable resorbable membrane as a potential alternative to the use of autogenous bone block grafts. Clin Oral Impl Res. October 2013:24(Supplement s9);153-154. DOI:10.1111/clr.12249.


    Read the study

  • Wessing et al. Clin Oral Impl Res. 2012 (Supplement s7)

    Wessing, B., Emmerich M, Sellhaus B, Bozkurt A. Study of a new collagen membrane with extended resorption time. Clin Oral Impl Res. October 2012:23(Supplement s7);211. DOI:10.1111/clr.12022.


    Read the study

  • Implantologie Journal 2011/12 Special Print

    Implantologie Journal Special Print (SPECIAL PRINT Edition 5/11 and 5/12 • Volume 16) - Dr med. dent. Bastian Wessing, Dr. med. dent. Martin Emmerich, MSc 

    “New Materials in GBR” and “Safe Bone Regeneration through a new Collagen Membrane”


    Download the publication

  • Jahrbuch Implantologie 2014 Special Print

    Jahrbuch Implantologie (SPECIAL PRINT Edition 2014 • Volume 20) - Dr med. dent Bastian Wessing, Dr med. dent. Martin Emmerich, MSc 

    “What is Guided Bone Regeneration (GBR) capable of today?”


    Download the publication

  • Prof. Christer Dahlin, Sweden

    “I really like the handling of the material. The fact that it doesn’t lose its shape when you place it is a great benefit. It gives you the possibility to take out the membrane and trim it. After a minute or so, when it is soaked, it attaches very nicely to the bone surface and no fixation seems to be necessary.”

  • Dr. Ramón Buenechea, Spain

    “It is a thin, easy to handle and quickly moistened membrane that maintains its properties as a barrier. It allows suturing and/or tag fixation, and is easily adapted to the bone defect.”

  • Dr. Angel Fernandez Bustillo, Spain

    “For over a decade I have used collagen membranes to achieve excellent results, and each type of membrane offered varying benefits. Nobel Biocare has managed to integrate most of them. I was surprised by its rapid and uniform hydration. It is easy to cut and it does not fold itself together. It is ideal for maxillary sinus lift and bone regeneration.”

  • Dr. Ali Tahmaseb, Netherlands (private practice, Antwerp, Belgium)
    “I like the membrane because it's very easy to handle compared with other membranes I’ve used. The most important thing for me is the extended resorption time – the membrane stays in place longer.”
  • Dr. Bastian Wessing, Germany
    “We are very excited about this new membrane. We have better results with creos xenoprotect than with the membranes we have used before. What I like is that the handling is very easy. The mechanical stability is very high and when it is rehydrated it adapts very well to the underlying bone.”
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